Simultaneous Estimation of Domperidone and Lansoprazole in Capsule Formulation by Hptlc Method
نویسنده
چکیده
A simple, fast, accurate and precise high performance thin layer chromatographic method has been developed for the simultaneous estimation of domperidone and lansoprazole in capsule formulation. This method allows the determination of 100-500 ng/spot of domperidone and 100-500 ng/spot of lansoprazole. The mobile phase composition was toluene:isopropyl alcohol:chloroform:acetonitrile (4:3:6:2). Densitometric analysis of domperidone and lansoprazole was carried out in the absorbance mode at 254 nm. The Rf values of domperidone and lansoprazole were found to be 0.22 and 0.76 respectively. The amounts of drugs present in the capsule and recovery studies were also carried out. The method was validated for precicion, accuracy and reproducibility.
منابع مشابه
Simultaneous Determination of Dexrabeprazole and Domperidone in Capsule Form by Using Hptlc and Mass Confirmation by Hptlc-ms
A rapid, quantitative and optimised high-performance thin-layer chromatographic method coupled to mass spectrometry using electro spray ionization (HPTLC/ESI-MS) for the separation and quantification of dexrabeprazole and domperidone in combined capsule dosage form has been developed and validated. The formulations were separated on silica gel 60 F254 plates using a saturated mixture of toluene...
متن کاملA Decision Tree for Rapid Quality Assurance and Control of Rifampicin-Containing Oral Dosage Forms for Global Distribution for Tuberculosis Treatment Y. ASHOKRAJ, SHRUTIDEVI AGRAWAL AND R. PANCHAGNULA 1-4 Transdermal Delivery by Iontophoresis
DOM in marketed capsule formulation. The assay values were in good agreement with the corresponding labeled claim. The recovery studies show accuracy of the method. On observing the validation parameters both the methods were found to be accurate, precise and speciÞ c. Hence the methods can be employed for quality control and routine analysis of lansoprazole and domperidone in pharmaceutical fo...
متن کاملRecent progress in simultaneous estimation of rutin, quercetin and liquiritin in Cocculus hirsutus by HPTLC
Background and objectives: Rutin, quercetin and liquiritin arepolyphenol flavonoids which have shown anti-inflammatory, antihepatotoxic, antiulcer, antiallergic, antidiabetic, antiviral and antioxidant activities. They are found in many herbal plants, one of them is Cocculus hirsutus. The objective of this research was to develop and validate a new, accurate, precise and economic HPTL...
متن کاملSimultaneous Spectrophotometric Estimation of Rabeprazole Sodium and Domperidone Maleate in their Combined Pharmaceutical
Two simple, rapid, economical, specific, precise and accurate spectrophotometric methods have been developed for simultaneous estimation of rabeprazole sodium and domperidone maleate in their combined pharmaceutical dosage forms. Rabeprazole sodium and domperidone shows absorption maxima at 285 nm and 287 nm respectively. The first method is based on the simultaneous equations. In the simultane...
متن کاملA Single Gradient Stability-Indicating Reversed-Phase LC Method for the Estimation of Impurities in Omeprazole and Domperidone Capsules
A gradient reversed-phase liquid chromatographic (RP-LC) method was developed for the quantitative estimation of impurities in the pharmaceutical dosage form of Omeprazole and Domperidone capsules. The developed method is a stability-indicating test method for the estimation of impurities generated during the formulation and storage of Omeprazole and Domperidone capsules. The chromatographic se...
متن کامل